Posts Tagged ‘PCRT’

Psychophysiologic Disorders and Controlled Research

Saturday, November 14th, 2015

Acceptance by the health care profession that Psychophysiologic Disorders (PPD) can be successfully diagnosed and treated will depend on completion of at least two randomized controlled trials (RCT).  The RCT is the gold standard method for documenting that a new form of treatment is superior to a placebo.  Only when a treatment passes this test and that passing is then confirmed by at least one additional RCT will clinicians consider making the effort to apply it to their patients.


American Psychosomatic Society (2)

Wednesday, March 10th, 2010

The 68th annual meeting of the American Psychosomatic Society got underway today with several presentations of interest.  First was a lecture that ties in with my recent blogs on assessing medical evidence.  The speaker presented studies that showed that people who took Vitamin E supplements for at least two years were about 40% less likely to suffer heart disease.  The researchers were well aware that people who take supplements are less likely to smoke and probably take better care of themselves in general.  So they attempted to account for those factors in every way they could using statistical techniques.  This gave their results enough credibility that they received wide attention from news media.  However, when this issue was studied using a PCRT (placebo-controlled randomized trial), which is a much more reliable method, the Vitamin E made no difference.  The speaker’s point was to be skeptical of results from population surveys because it is nearly impossible to account for all confounding factors.  He went on to talk about using genetic markers to make those surveys more reliable and accurate.


Assessing Medical Research (3)

Friday, March 5th, 2010

Published medical research can be designed in a variety of ways but the greatest credence is given to placebo-controlled randomized trials (PCRT).  Ideally, and in simplest form, this design has the following characteristics: (more…)